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KMID : 0378120030300020179
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Chungnam Medical Journal
2003 Volume.30 No. 2 p.179 ~ p.186
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Changes of TSH Binding Inhibitory Immunoglolulin Following Radioiodine Treatment in Patients with Graves’ Disease
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Jo Young-Suk
Kwon Ki-Hyun
Lee Jun-Chul
Rha So-Young
Lee Hyo-Jin
Hong Woo-Jeong
Lee Yeu-Seon
Kim Koon-Soon
Shong Min-Ho
Kim Young-Kun
Ro Heung-Kyu
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Abstract
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Prediction of thrapeutic response to radioiodine in Graves’ disease is poorly understood. Although thyrotropin binding inhibitor immunoglobulin(TBII) level is a strong index for relapse after antithyroid drug medication, conflicting results are reported regarding its prognostic significance in Graves’ disease treated with RAI. This study is dengned to evaluate possible relationship between post-treatment hypothyroidism and TBII in Graves’ disease treated with RAI.
Fourty two patient with Graves’ disease after radioiodine treatment were studied retrospectively. The subject were divided into hypothyroid group and euthyroid or hyperthyroid group. We evaluated the association of hypothyroidism and TBII with radioiodine treatment dose.
The mean age of hypothyroid group was 48±11 years and euthyroid or hyperthyroid group was 47±12 years. There was no difference in two groups. And there was no significant difference in post- treatment TBII between two groups(49.9±28.5%, 29.9±14.3%, p-value >0.05). The treatment-dose had no influence on post-treatment thyroid state. Euthyroid or hyperthyroid group was done with 13.6±6.9mCi and hypothyroid group was 17.0±10.4mCi(p-value > 0.05).
TBII had no prognostic significance on long-term hypothyrodism in Graves’ disease treated with radioiodine. And, treatment-dose had no influence on post-treatment thyroid state.
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KEYWORD
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Graves’ disease, Thyrotropin binding inhibitor immunoglobulin(TBII), Radioiodine treatment
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